• CHEMISTRY LABS

M2i has a surface area of 150 m2 at the Lacq site equipped with low-level or conventional fume hoods dedicated to chemistry R&D.

Specific equipment dedicated to hydrogenation:

• 10 to 300 ml autoclave up to 150 bars at 200 °C
• Autoclave 1.5 L 30 bars 150 °C

Preparative HPLC chromatography:

• Prochrom system with dynamic axial compression 50 diameter with computer guidance and UV detection.

Rotary evaporator:

• Büchi R 153 – 10 L capacity.

1 to 6 L twin-jacketed glass reactors equipped with injection pumps and monofluid for heating/cooling (-60/+150 °C)

PILOT In order to assist its clients in synthesising larger amounts of product for validation of process scale-ups or in preparing clinical batches, M2I Development has pilot capacities of up to 20 L. A first pilot is equipped with enamelled reactors of 50 and 250 L functioning in accordance with cGMP standards. They are combined with 600 diameter single-layer filters and a laminar-flow high-ceilinged drying room equipped with a vacuum oven or a Guedu-type 100 L filter-dryer. Temperature ranges are -20 °C to +150 °C. This pilot is combined with a storeroom fitted with a sampling room and a batch preparation room with separate quarantine and storage areas for raw materials and finished/semifinished products.   A second pilot equipped with 70 and 170 L enamel reactors (-20 °C/+150 °C) and 20 L twin-jacketed reactors (-60 °C/+150 °C) is available for non-GMP syntheses. It is also equipped with polypropylene 600 diameter single-layer or 20 L glass filters (115 L).

• ANALYTICAL EQUIPMENT

The analytical department is equipped with the following instrumentation:

• Analytical HPLC (UV and diode arrays) with a panel of columns in normal and inverse phase and chiral columns.
• Preparatory HPLC on different stationary phases.
• CPG, CPG/Headspace: panel of stationary phases HP-5,HP-1, DB-WAX, volamine, chiral, etc.
• UV spectrophotometer
• pH-meter
• Melting point
• Karl Fischer
• Potentiometric titrator